Born in Larissa, Myrtò Papatanasiu began her musical studies at the conservatory there. She studied singing at the State Conservatoire of Thessaloniki and musicology at the Aristotle University, and continued her studies in Milan under Roberto Coviello.

She has performed in major international theatres, including the Vienna State Opera, Theater an der Wien, Munich State Opera, Berlin State Opera, Sydney Opera, Netherlands Opera in Amsterdam, Zurich Opernhaus, Carlo Felice Genoa, Rome Teatro del Opera, Tokyo National Theatre, Konzerthaus of Vienna, Copenhagen Royal Opera, La Monnaie in Brussels, Turin Teatro Regio, Staatstheater of Stuttgart, Teatro Comunale, Bologna and many others.

She has worked with many important directors including Franco Zeffirelli and David Mac Vicar. In 2012 she was proclaimed winner of the Maria Callas: Best Début Artist of the Year. Her CDs and DVDs include Rossini’s Il Turco in Italia, Don Giovanni, Beethoven’s Choral Symphony and Rossini’s Semiramide.